Dermorphin

Description

Dermorphin is a naturally occurring heptapeptide first isolated from the skin of South American tree frogs (Phyllomedusa species). It is notable as one of the most potent naturally occurring opioid peptides, exhibiting approximately 30-40 times greater affinity for mu-opioid receptors (MOR) than morphine. Dermorphin contains a D-alanine residue at position 2, making it one of the few known naturally occurring peptides to contain a D-amino acid, which confers significant resistance to enzymatic degradation. The peptide acts as a highly selective mu-opioid receptor agonist, making it a valuable pharmacological tool for studying MOR-mediated signaling, pain pathways, and opioid receptor pharmacology. Research has used Dermorphin and its analogs to map opioid receptor distribution and study MOR-specific physiological responses. Supplied as a lyophilized powder. For research use only.